A million dollars in pharmaceuticals is hijacked from a cross-country truck. The Angels are called in to help the Venus Trucking Company that employs all women drivers. The company is owned and operated by Maggie Brill. Kris and Tiffany drive a big rig -- following the route of the hijacked truck. They see some suspicious country boys and follow them into a truck stop where Kelly is posing as a waitress. When a fight occurs, and they are distracted, an identical Venus rig is switched with that being driven by the Angels. Kris and Tiffany drive away, unaware of the switch -- but Kelly gets word and warns them on the CB Radio System. Kris in turn uses the CB to help track down their real rig. Other truckers help. They find the cargo, capture the thieves and confront and arrest Maggie who had masterminded the hijacking of her own trucks.
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