Dean Martin, as casino boss Frank Howell, is unnerved by the violent deaths of his closest friends. When showgirl Mary Phillips is killed in a mysterious car crash, the Angels fly to Vegas and go undercover at the Tropicana. An unidentified motorist takes a potshot at bitter comic Joey January - is it serious, or just another ruse to get out of his contract with Frank? Howell's old gambling buddy Gyp suffers hit-and-run injuries, and is then fatally overdosed by an intruder in his hospital room. Financial ruin threatens as Mark Haines, Frank's rival in love and business, brings in craps genius Professor Perkins. While Sabrina is out boating with Frank, Kris, and veteran crooner Marty Cole, a gunshot warns that her budding romance with Frank could prove hazardous to her health. She returns fire, but Marty secretly sabotages the motor. When Kris and Marty disappear under ominous circumstances, Sabrina and Kelly force thug Ed Slocum to take them to Marty. In a crazed attempt to avenge his wife's recent auto death, Marty has sought to emasculate Frank. Dying from gunfire, he still falsely believes that his wife Leslie deliberately smashed up because of guilt over an anticipated affair with Frank.