On Thanksgiving, the harried staff struggles with a shortage of doctors. Abby treats an HIV-positive woman, Loren (Amy Pietz - Caroline in the City), who is hemorrhaging and may be pregnant. A horrifying accident very nearby threatens to engulf everyone in the hospital. Nearby, Lewis is unaware that her ex-husband, Chuck (recurring guest star Donal Logue), is involved in the flaming disaster. Meanwhile, Romano threatens to file a serious complaint against the brash Pratt and continues to taunt Abby with tough medical questions--even as she wonders what Carter might be doing that same day in Africa.