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Tim (Ben Stiller) and Nick (Jack Black) are best friends, neighbors and co-workers, whose equal footing is suddenly tripped up when one of Nick's harebrained get-rich-quick schemes actually succeeds: Vapoorizer, a spray that literally makes dog poop, or any other kind for that matter, evaporate into thin air to where exactly is anyone's guess. Tim, who had poo-pooed Nick's idea and passed on an opportunity to get in on the deal, can only watch as Nick's fortune and Tim's own envy grow to equally outrageous proportions. The flames of jealousy are fanned by an oddball drifter (Christopher Walken) who takes it upon himself to help fix Tim's situation, but only causes Tim's life to careen more wildly out of control...and Nick's with it.