A very-much-in-love Ephram discovers that he has unwittingly become a girlfriend to Amy, but the friendship takes a turn for something more when a moment of intimacy leads to lovemaking. Meanwhile, Nina grows suspicious of Jake's (recurring guest star SCOTT WOLF) recent strange behavior, which is further amplified when his brother, Brian (TOM PARKER), shows up unexpectedly. Delia befriends the popular girls in school, which worries Dr. Brown. Bright tries to rectify Hannah's (recurring guest star SARAH DREW) low self-esteem issues. And Rose gives Dr. Abbott startling news that could drastically change their lives.