After a 200-year-old medicine jar found on an off-shore shipwreck shatters in a teenage girl?s palm, she is admitted to Princeton Plainsboro for symptoms closely linked to smallpox. When the Center for Disease Control?s Dr. Dave Broda (guest star Dylan Baker) institutes a lockdown on the hospital and suspends House?s team?s ability to diagnose, Masters (guest star Amber Tamblyn) grows suspicious of Broda?s motives and becomes convinced that the patient is suffering from a different disease. The girl?s father soon experiences similar symptoms, and House is forced to make a precarious decision that puts his own life in jeopardy. Meanwhile, Wilson and Sam (guest star Cynthia Watros) comfort a 6-year-old chemotherapy patient who prompts them to examine their relationship.
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