House and his team take on a new patient, Bob, who comes to Princeton Plainsboro Teaching Hospital after suffering from a breathing attack while role-playing in the bedroom with his wife (guest star Samantha Mathis). All the symptoms point to heavy metal poisoning, but the tests do not. Meanwhile, as the team goes through its diagnostic process, House is wreaking havoc in the clinic, telling a patient that he got a sexually transmitted disease from his wife. When the wife confronts House about it, he tricks the patient and his wife into divulging the truth. In addition, Wilson has moved in with House and things are not going too smoothly. After House and his team treat Bob for a number of things, including food allergies and lupus, with no results, House is still sure it's heavy metal poisoning. When all the usual metals turn up negative, House confronts Bob's wife as to the origin of Bob's deadly illness, and all signs point to the wife.