When a young man comes into the hospital severely burned, but with some unusual activity going on in his blood tests, House and his team have a difficult challenge. How can you diagnose a burn victim when you are unable to use your normal testing methods? The team must get very creative to figure out how to test the patient before his body shuts down. To complicate matters further, House is intent on proving that a former colleague from medical school's new migraine drug doesn't work. Determined to prove the ex-colleague wrong, House makes himself the guinea pig of his own unofficial tests, with painful results.