House and the team encounter a woman admitted to Princeton-Plainsboro after she collapsed at her wedding. Her test results come up negative for a variety of common diseases, which leads the team to suspect foul play. When they discover the woman had been a music producer living in the fast lane until she converted to Hasidic Judaism, House insists that people do not change so easily, and that her seemingly rash decision may have something to do with an underlying condition. The woman's husband insists that House treat his wife for her illness, rather than for her past, but she continues to fall dangerously ill. The team must run through all possible diagnoses without disturbing her newly found religious beliefs before it is too late. Meanwhile, House is preoccupied by Wilson's newly-outed relationship with a woman whose personality is remarkably similar to House's in the Don't Ever Change episode of HOUSE. Viewer discretion is advised.
Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase; Peter Jacobson as Dr. Chris Taub; Kal Penn as Dr. Lawrence Kutner; Olivia Wilde as Thirteen.
Guest Cast: Laura Silverman as Roz; Eyal Podell as Yonatan; Faye DeWitt as Mrs. Silver; Karen Strassman as Female Guest #1; Heather Sher as Female Guest #2; Bobbin Bergstrom as Nurse.