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House and the team take on the case of Morgan (guest star Judy Greer) who works in a nursing home with a pet cat who only sleeps next to people if they are about to die and does so with alarmingly accuracy. When it seems the cat has predicted her own death, Morgan, convinced she is about to die, fakes a seizure in order to get to House to have him diagnose her before it's too late. House dismisses her as a nut job, but is intrigued with the claim about the cat and sets out to disprove Morgan's theory. When she falls seriously ill, he and the team are forced to get to the bottom of her mysterious illness as well as the mystery of the cat with the kiss-of-death. Meanwhile, Taub struggles with his finances and reconnects with an old high school friend at the clinic whose business successes present Taub with an entrepreneurial opportunity he had not previously considered.