House and the team treat a woman who suffers from a sudden paralysis of the hands that causes an injury to her daughter while she's spotting her at an indoor rock-climbing wall. As House probes the woman and her injured daughter for any leads as to what might be causing her condition, House is convinced that the woman is withholding information. When the woman's daughter reveals some very descriptive details about her mother's personal life, House isn't so sure the woman hides anything about herself from the people around her, especially her daughter. As the team runs tests to find out what caused her paralysis, the woman loses her eyesight and her system begins to shut down, and House and the team are baffled as to whether it is the woman herself, or her own physiology that is lying to them. Meanwhile, House lets his team participate in a Secret Santa gift exchange, but he puts his own twist on the holiday tradition in the It's a Wonderful Lie episode of HOUSE. Viewer discretion is advised.
Cast: Hugh Laurie as Dr. Gregory House; Lisa Edelstein as Dr. Lisa Cuddy; Omar Epps as Dr. Eric Foreman; Robert Sean Leonard as Dr. James Wilson; Jennifer Morrison as Dr. Allison Cameron; Jesse Spencer as Dr. Robert Chase; Peter Jacobson as Dr. Chris Taub; Kal Penn as Dr. Lawrence Kutner; Olivia Wilde as Thirteen.
Guest Cast: Janel Moloney as Maggie; Liana Liberato as Jane; Cheyenne Wilbur as Minister; Scotty Maguire as Bystander, Jennifer Hall as Melanie; Anthony Starke as Roger; Bobbin Bergstrom as Nurse
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