As House and his team work on the diagnosis of Vince, a man with a giant swollen tongue, disgruntled former patient Jack Moriarty (guest star Elias Koteas) walks into House's office and shoots him. House continues to treat Vince from his hospital bed in the ICU with Moriarty, shot by hospital security and handcuffed to his bed, as his roommate. Mysteriously since the shooting, House feels decreased pain in his leg. However, aftereffects of the shooting begin to affect him negatively and he starts to question his own ability to diagnose, while hostility increases between him and Moriarty. As Vince's body begins to deteriorate, House struggles through his own self-doubts and must trust his team to find a way to solve the case.