At Cameron's urging, House and the team take on the case of a man living with such severe chronic pain that he tries to kill himself, unable to go on after living for years without a diagnosis or any relief from his suffering. As they try to determine whether the man's pain is psychosomatic or caused by a physical disease, parallels between the patient and House's experiences with excruciating, prolonged pain become apparent. When the patient again attempts suicide under the team's care, their search for answers becomes urgent. Meanwhile, Foreman and Thirteen explore their now complicated relationship as they work together on the Huntington's disease clinical drug trial, and Cuddy finds that taking care of her newly adopted baby leaves her little time to run a hospital and baby-sit House at the same time.
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