House and the team take on the case of Nick (guest star Jay Karnes), a book editor who loses his inhibition and starts insulting coworkers at a dinner party one night before falling ill. The team realizes Nick has frontal lobe inhibition, which has caused him to lose his filter and vocalize all of his innermost thoughts, resulting in extremely insulting outbursts. As Nick's free speech lends to some amusing and insightful comments regarding the team, he must deal with the consequences of being unable to lie to his wife and everyone else important in his life. Meanwhile, House suspects Wilson and Taub are keeping something from him when he catches them both in a lie. House is determined to get to the bottom of it.