For dangerous and depraved loner Kenneth (Andrew Lee Potts), life at the hospital where he works is a series of endless torments from a group of ambitious medical students. But when they decide to teach him a lesson, he ends up in a coma and practically brain dead. Guilt-ridden Catherine (Kebbel), determined to save his life, administers a powerful and untested cocktail of drugs to the coma victim. Rather than cure him, however, it triggers a powerful out-of-body experience and enables Kenneth to temporarily inhabit other people's bodies and, through them, take revenge on those responsible for his vegetative state.
As her colleagues are savagely picked off one-by-one, Catherine soon realizes what started as a medical miracle has now transformed into a medical monstrosity. She is forced to confront a comatose killer who moves in and out of bodies at will, getting ever closer to her as his supernatural powers increase.
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