Leonard (Pearce) is an insurance investigator whose memory has been damaged following a head injury he sustained after intervening on his wife's murder. He can now only live a comprehendible life by tattooing notes on himself and taking pictures of things with a Polaroid camera. The movie is told in reverse - as Leonard's memories come to him. Leonard badly wants revenge for his wife's murder. However, there may be little point if he won't remember to enjoy his revenge.