Captain Stottlemeyer and Lieutenant Disher are making a routine arrest when a mysterious man in a car drives up and shoots at them, wounding Stottlemeyer. With Stottlemeyer in the hospital, Monk joins Disher in an intense investigation. Their prime suspect is the man Stottlemeyer and Disher were trying to arrest at the time of the shooting, a biker who was attempting to skip bail. When Monk and Disher try to apprehend the biker, Monk's obsessive-compulsive disorder allows the suspect to escape. Consumed with guilt, Monk goes to Dr. Kroger (Stanley Kamel) for help. Dr. Kroger gives Monk some pills that help people with O.C.D., and Monk reluctantly tries them. The pills work, and soon Monk becomes a completely different person. He's more relaxed, and his fears and phobias seem to be gone. But despite the benefits, there's one key cost: Monk has lost his ability to solve crime.