As Sean celebrates Christmas without his family, his loneliness leads him to seek solace in alcohol--resulting in possible legal action from a patient. Meanwhile, Christian receives an unexpected gift when Wilber (recurring guest star Josiah Henry), who is now 3 years old, comes back into his life. And taking drastic measures to fill her holiday kidney quota, James (recurring guest star Jacqueline Bisset) forces Michelle (recurring guest star Sanaa Lathan) to help. Recurring guest star Alanis Morissette appears as Poppy. Charles Haid guest stars as Reefer.
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