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Queer Eye's Fab Five combine their powers to help a truly deserving couple. Anne Marie and straight guy Michael are life long friends turned lovers who became the ultimate all-American couple. When Anne Marie's cancer diagnosis troubles their fairy tale romance shortly after the honeymoon, Michael stays by her side and remains her rock through her seven months of chemotherapy. Anne Marie, now cancer-free and healthy, is looking to repay her husband with a Queer Eye makeover specially designed for the man that has sacrificed it all for love. In an effort to take the attention away from her illness and their challenging year-and-a-half, the Fab Five help her celebrate her incredible husband Michael and their true love with a makeover, topped off with a very special second honeymoon.