Shawn Black (Matthias) knows pain. His parents and brother were killed in front of him. Beaten, bloodied and left for dead by a gang of ruthless vampires led by the charismatic Cain (Jones) and his lethal lieutenant Vanya (Kat Von D). But like his would-be murderers, Shawn has come back from the brink of death to take his revenge. He soon comes upon Reverend Roy (Madsen), who reveals to Shawn his calling as a "slayer," the only human capable of truly destroying vampires.