Sheriff Mills calls Sam and Dean after she kills a vampire who attacked a prisoner named Annie.
Even though Castiel is still furious, Metatron attempts to recruit Cas to join forces with him with the promise of restoring his grace to its former glory.
Dean struggles with the after effects of the Mark of Cain, while Sam hears about a case where straight-laced people are turning into violent murderers.
Dean is frustrated when he can’t reach Crowley, who has promised to find The First Blade, but finds out soon that Crowley fell off the wagon and needs his help.
A teenage girl is killed and the final selfie she took before the attack shows a ghostly figure in the background, which brings Dean and Sam to Washington.
Sam and Dean listen to a message on John's cell phone from a woman named Ellen (guest star Samantha Ferris)and decide to track her down. They are shocked to discover Ellen runs a road house that also serves as a gathering place for hunters like themselves. Meanwhile, at a small town carnival, a demonic clown is persuading children to let them into their home so he can murder their parents.
In the aftermath of the car crash, the surviving Winchesters go to the hospital, where one is stalked by a Reaper while another must consider sacrificing himself to save the others.
Meg turns to killing John's friends in order to get the Colt. Sam and Dean stakeout the Demon's next target; a family with a six month old baby showing signs of special abilities. John heads off alone to confront Meg.
Sam and Dean seek help from Bobby Singer, an old family friend in their mission to save their father from Meg. The brothers set a trap for Meg.
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