Sam and Dean stumble into starring roles on a gritty reality show called "Ghostfacers," which chronicles the pursuit of the paranormal.
Sam and Dean break into Bela's (recurring guest star Lauren Cohan) apartment in order to get the Colt back, but she has tipped off Agent Henricksen (recurring guest star C. Malik Whitefield) to their whereabouts, and the brothers are arrested.
While Sam and Dean are investigating the disappearance of a man from a tourist location, Dean is shot and killed.
When Bobby falls into a coma and can't be awakened, Sam and Dean race to his side.
Sam and Dean travel to Sturbridge, Massachusetts, and discover a coven of witches that has killed two people.
It's Christmas time and, as Sam and Dean investigate a series of murders where the victims have been pulled up through the chimney, Sam realizes they are dealing with a sort of anti-Santa, a demon with roots in pagan lore.
Sam and Dean capture a female vampire named Lucy (Mercedes McNab - "Buffy the Vampire Slayer") who claims to have no knowledge of how she became a vampire.
Sam and Dean investigate the mysterious demise of drowning victims who were nowhere near water at the time of their death. The brothers learn that each of the victims saw a ghost ship shortly before they died.
Sam and Dean investigate a small town that has been plagued by a number of strange murders resembling fairytales like Little Red Riding Hood, Snow White and Hansel and Gretel.
Sam and Dean investigate a rash of violent deaths in Elizabethville, Ohio, a once-sleepy town that has become a haven for gamblers and drinkers.
Sam and Dean answer a call on their father's old cell phone, alerting them that someone has broken into their dad's secret storage room in New York. They discover that a cursed rabbit's foot has been stolen and call Bobby (recurring guest star JIM BEAVER) for help.
Dean pressures Sam into traveling to Cicero, Indiana, so Dean can visit an old flame named Lisa (Cindy Sampson), with whom he had a tryst nine years ago.
In the third season premiere, bracing themselves for the possibility of an apocalyptic war, Sam and Dean realize they have an enormous task: hunting down the hundreds of demons that escaped from the Devil's Gate.
Brothers Sam and Dean Winchester were raised to be soldiers. Now, as they join other hunters traveling the country to track down the evil fugitives from Hell hiding in the darkest corners of America, they must also battle their internal demons.
While dealing with the aftermath of the fight between Sam and Jake, one of the powerful people from the ghost town, Dean pays a steep price for his involvement.
Sam is abducted by a yellow-eyed demon and finds himself in a ghost town with children who have special abilities. They learn that the demon has brought them together to initiate his endgame.