Sam and Dean investigate the appearance of a young female ghost in an abandoned house, but things become more complicated when a family moves in.
Anna (Julie McNiven) recalls her past and Sam and Dean understand why Castiel (Misha Collins) and Uriel (Robert Wisdom) want her dead. Alastair (Mark Rolston) gets closer.
Ruby (Geneviev Cortese - "Wildfire"), Sam and Dean look for a girl (Julie McNiven - "Mad Men") who hears the angels. Castiel (Misha Collins) and Uriel (Robert Wisdom) return.
Sam and Dean investigate a small town where a wishing well works so well that a teddy bear comes to life, someone wins the lottery and the town geek gets a hot girlfriend. The brothers realize, however, that while everyone is happy now, the end result could be disastrous.
The brothers deduce a witch is sacrificing people to summon a dangerous demon. Robert Wisdom ("The Wire," "Prison Break") guest stars as Uriel, a specialist angel.
Dean is infected with an illness that starts as anxiety, but moves to full-blown terror that stops the heart. Sam and Bobby (JIM BEAVER) must find the root before Dean dies.
Shown entirely in black and white, Dean and Sam investigate several murders at Oktoberfest. The first victim was found with bite marks on her neck, much like a vampire would leave, while the second victim has wounds that look like a werewolf attack. After a mummy rises from his crypt, Dean determines that a shape-shifter demon is terrorizing the town as iconic monsters from the old Hollywood movies.
Sam and Dean find that a family man (guest star Dameon Clark - "24," "Prison Break," "Dragon Ball Z" series), is turning into a flesh-eating monster, and argue about killing him.
Dean is transported back in time and is shocked when he lands in Lawrence, Kansas. However, that shock turns to amazement after he runs into a young John Winchester (guest star Matthew Cohen - "South of Nowhere," "Medium") and Mary (guest star AmyGumenick - "Greek") who have just fallen in love. Dean isn't sure why he was sent back so he begins to enjoy the time with his parents and newfound grandfather (guest star Mitch Pileggi - "The X-Files," "Stargate: Atlantis"), who may be hiding a secret that is key to Sam and Dean's entire predicament.
Sam and Dean are stunned when the spirits of Meg (recurring guest star Nikki Aycox - "Cold Case," "Ed") and Agent Henricksen (recurring guest star C. Malik Whitfield - "The Guardian") appear and accuse the Winchesters of failing them. Although rattled, the brothers must pull together to save Bobby (recurring guest star Jim Beaver), who is too crippled with guilt to fight off the angry ghosts of the young children he couldn't save.
In the fourth season premiere, it's been four months since Dean was dragged away by the hounds of Hell, the result of a deal he made with the Crossroads Demon in exchange for his brother's life. Now, Dean wakes up in a pine box. He's been freed from Hell, but he doesn't know how or why. He has a joyful reunion with Sam and fellow demon hunter Bobby (recurring guest star JIM BEAVER), but it isn't long before the three start to really wonder what exactly pulled Dean from Hell -- and what it will want in return.
Dean's deal with the crossroads demon is up in 30 hours and Dean, Sam and Bobby (recurring guest star Jim Beaver) search for Lilith, who holds the contract. They discover her location and Sam summons Ruby (recurring guest star Katie Cassidy) for help, despite Dean's protests. Ruby warns them that they aren't yet ready to fight Lilith, but they steal her knife and depart for New Harmony, Indiana. In a battle to the death, Sam, Dean and Bobby take on Lilith and all her demons in a last ditch effort to save Dean's life.
As time runs out for Dean, Sam convinces him to head to Erie, Pennsylvania, to investigate a possible zombie case. Instead, they discover Doc Benton (guest star Billy Drago - "Charmed"), a real-life doctor who, in 1816, abandoned his medical practice to follow his obsession with finding the key to eternal life by drugging people and stealing their vital organs. Meanwhile, Bobby (recurring guest star Jim Beaver) finds out where Bela (recurring guest star Lauren Cohan) is hiding, and Dean heads out to confront her, leaving Sam behind to deal with the good doctor. Dean and Bela battle it out for the last time, and Dean leaves Bela in a desperate, possibly fatal, position.
Dean is stunned to receive a phone call from his dad, John (Jeffrey Dean Morgan), who says he has a solution to get Dean out of his deal. Sam is skeptical.
Sam and Dean stumble into starring roles on a gritty reality show called "Ghostfacers," which chronicles the pursuit of the paranormal.
Sam and Dean break into Bela's (recurring guest star Lauren Cohan) apartment in order to get the Colt back, but she has tipped off Agent Henricksen (recurring guest star C. Malik Whitefield) to their whereabouts, and the brothers are arrested.
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