In the sixth season premiere, Charlie encounters an ex-girlfriend (RENA SOFER "24") whose son looks an awful lot like him. MARTIN MULL ("Roseanne") guest stars as Charlie's pharmacist.
The swinging-bachelor lifestyle of commercial-jingle composer -- and chronic gambler -- Charlie Harper (Sheen) was sorely disrupted when his Malibu beach house was invaded by his uptight brother, Alan (Cryer), and Alan's ten-year-old son, Jake (Jones). Given the childish hedonism of Charlie and the domestic immaturity of the soon-to-be-divorced Alan, young Jake turned out to be the true "grown-up" in the Harper household.
Charlie tries to resist temptation when he meets the grown daughter of the woman he's dating (SUSAN BLAKELY) and realizes they've met before. JANE LYNCH guest stars as Dr. Freeman.
Charlie finds himself attracted to Angie (recurring guest star SUSAN BLAKELY), an older woman who writes self-help books. Meanwhile, Alan and Jake battle over a school assignment.
A CSI team investigates a mysterious death at Charlie's house. George Eads ("CSI: Crime Scene Investigation") makes a cameo appearance.
Alan plans Evelyn's wedding to Teddy (ROBERT WAGNER), while Charlie pursues his future stepsister and Teddy's devious daughter, Courtney (JENNY McCARTHY).
Alan worries that Charlie's womanizing is out of control. JANE LYNCH returns as Charlie's therapist, and EMMANUELLE VAUGIER returns as Charlie's former fiancée, Mia.
Charlie goes with Jake on a double date and sets Alan up with a prostitute. Recurring guest star MELANIE LYNSKEY appears as Rose.
Alan dates one of his ex-wife's friends who reveals a secret about Judith's sex life. Recurring guest star RYAN STILES appears as Judith's second husband.
Rose (recurring guest star MELANIE LYNSKEY), Charlie's lovable stalker, is back from England and takes strange care of a very sick Charlie.
Seeing Alan not fully passionate about his relationship, Charlie coaches Alan in the fine art of breaking up with a woman.
While trying to help Jake get over a breakup, Alan discovers that it was Charlie who stole his high school girlfriend. Alan seeks revenge on Charlie by following the same advice Charlie dispenses to Jake.
After Evelyn and Teddy become engaged, Charlie struggles to fight his attraction to Teddy's daughter, Courtney, Charlie's soon-to-be stepsister.
Charlie finds success as a children's singing star, making Alan miserable. Guest star RICHARD KIND ("Spin City") appears as Artie, an executive at Charlie's record label.
Charlie and Alan argue over Alan's place in the house, prompting Alan and Jake to move in with Evelyn. Recurring guest star ROBERT WAGNER appears as Teddy, Evelyn's boyfriend.
Charlie's girlfriend, Linda (recurring guest star MING WEN), is embarrassed to be seen in public with him. Meanwhile, despite Alan forbidding it, Jake sneaks out to a concert.
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