Doogie turns 18, and hopes to lose his virginity—with Wanda—for his birthday.
Vinnie and Janine convince Doogie to ask Wanda to the prom. Doogie is impressed by a young girl with a strong will to live who is awaiting a heart transplant.
Vinnie cheats on Janine. Janine winds up in a passionate kiss with Doogie. Raymond meets his estranged father at the hospital.
Vinnie is nervous about being accepted to film school. Doogie is excited that the Hollisters are finally having a baby.
McGuire resigns from Eastman and joins the Physicians Flying Service, where he feels his work will be of greater importance. Meanwhile, Doogie is frantic to find a date for the annual hospital dance when Michele dumps him.
Mrs. Howser gets a job as a patient advocate at the hospital, and Doogie and his father have mixed feelings about it.
Dealing with the loss of her mother, Wanda no longer has time to go out with Doogie. So he asks a student nurse to attend the hospital's Monte Carlo Night with him.
Mrs. Howser's parents, Don and Irene, drop by for a surprise visit while the Howsers are having their kitchen remodeled. Don promptly offends the contractor, who quits on the spot.
Vinnie manages to convince Doogie and Dr. Howser to take him along on their annual father-son vacation.
The hospital's board of directors is very pleased with the mural project it has instituted at the medical center for children patients -- until it is discovered that the artist has AIDS.
Doogie reluctantly agrees to play in the big championship basketball game with St. Michael's Hospital, despite the fact that he is far from an athlete.
Plans for the class formal are dashed when Wanda's mother is killed in an automobile accident.
Doogie and Vinnie are faced with a dilemma: Do they tell Dr. Howser that Vinnie had an accident with Doogie's car?
Doogie is attracted to Lisa, a nursing student at the hospital, and asks her out on a date without telling Wanda. A patient who checks into the hospital has two wives, each unknown to the other.
Vinnie is looking for someone to write a recommendation letter for his application to N.Y.U. Film School. Coincidentally, the head of ABC-TV programming has just been admitted to the hospital.