The crew comes to the aid of a bordello when its madam, an old acquaintance of Inara's, asks for help after a gunslinger claims a prostitute’s baby is his and he's taking it because his wife is barren.
While Jayne opens a mail package from his mother that contains a wool cap with ear flaps and a pom-pom, Mal and Zoe open their package to discover the body of their old war buddy, Tracey.
Mal is shocked to discover his old friend's new bride is Saffron who, although furious after Mal blows her cover, offers to cut Mal in on what she calls the perfect, big-time scam.
The crew of Serenity is eager to rid themselves of an easily traceable cargo they salvaged from a vessel adrift in space, totally unaware that a passenger has brought an even more dangerous cargo aboard.
The crew is caught off-guard when a bounty hunter, eager to claim the enormous reward on River's head, sneaks aboard Serenity and methodically begins taking the crew prisoner one by one.
Wash regrets insisting he be allowed to accompany Mal on a mission after the two men are captured by Adelai Niska—the client who previously hired Mal to steal the medicine bound for Paradiso.
Simon offers the crew a proposition: if they help him sneak River into a hospital so he can run tests on her, he'll tell them where to find medical supplies that will fetch an enormous price on the black market.
When Simon is kidnapped by a group of villagers in need of a doctor, Serenity is forced to make contact with an Alliance ship in order to seek medical help for the critically wounded Book.
In order to secure a job transporting cargo off-planet for a client, Mal attends a social event where a dance with Inara leads to him being challenged to a swordfight in defense of her honor.
After an explosion leaves Serenity crippled, Mal orders everyone to abandon ship while he stays behind in an attempt to make repairs-and reminisces how he found the ship and picked its crew.
When the crew returns to a planet where Jayne participated in a heist gone bad, they're shocked to discover that Jayne's past actions have turned him into a local hero of Robin Hood-like mythic proportions.
After a celebration in which the crew is honored for ridding a planet of a group of bandits, they return to Serenity to find a woman named Saffron who claims that Mal married her during the festivities.
After encountering a booby-trapped spacecraft carrying the lone crewmember of a horrific Reaver attack, Serenity is boarded by an Alliance Commander looking for Simon and River.
Mal has second thoughts after discovering that two boxes of Alliance goods his crew has been hired to steal are full of badly needed medical supplies headed for the mining town of Paradiso.
The crew of a spaceship, Serenity, take on a mysterious new passenger and find themselves under attack as they travel the galaxy.