The crew comes to the aid of a bordello when its madam, an old acquaintance of Inara's, asks for help after a gunslinger claims a prostitute’s baby is his and he's taking it because his wife is barren.
A bounty hunter named Jubal Early sets his sites on capturing River Tam and manages to sneak aboard the Serenity in deep space.
The Serenity goes to the moon of Deadwood to answer a distress call from Inara's old friend who runs a brothel.
What starts out as a nice day at a space station goes very wrong when Mal and Zoe receive the corpse of their old war buddy in the mail.
Mal has to make a tough choice in whether he should trust Saffron when she offers the Serenity crew an opportunity to make a lot of money on a risky job.
Tensions begin to run high on board the Serenity when Wash finds himself feeling threatened by the closeness between Mal and Zoe.
On return to Ariel, Simon hires the crew out to smuggle River into a hospital so Simon can figure out what the Alliance did to her.
The Serenity engine explodes, leaving the crew low on oxygen and adrift in deep space.
Things go terribly wrong during a job on an outer planet; both Simon and River are kidnapped by the locals in need of a doctor, while the rest of the crew finds themselves in need a doctor of their own.
On a mission to transport some goods on the planet Persephone, the Serenity crew attend a ball where Mal finds himself at odds with one of Inara's "clients".
The Serenity crew pulls a job in a town where Jayne once made some friends and few lifelong enemies.
Mal unwittingly marries a beautiful village girl during a job in the backwater. But the surprises don't end there. Christina Hendricks guest stars.
The Serenity crew is coerced into pulling a train robbery. When they discover the stolen cargo is actually medicine intended for refugees, they are forced to reevaluate their priorities.
In desperate times, the crew of Serenity is transporting passengers to another planet, only to discover that one of them has smuggled something strange in their cargo.
The crew of a spaceship, Serenity, take on a mysterious new passenger and find themselves under attack as they travel the galaxy.
Sci-fi western set 500 years in the future, in the aftermath of a universal civil war, that centers on the renegade crew of a small transport spaceship.