Arizona struggles to convince Callie to take her back.
While standing in the middle of a symbol of their future, Meredith tells Derek that they could be extraordinary together. The gesture works; McDreamy is going to break it off with Rose.
Addison is cheating on Derek with Mark.
Jackson's almost death has stirred something inside April. She wants Jackson, but is engaged to another man. Jackson just needs to give a reason for her not to marry Matthew and they could be together.
Highlights from some of ABC's most exciting dramas. Grey's Anatomy Season Premiere Thursday Sept 26 at 9|8c on ABC.
Readiness Is All - sneak peek
Actor James T. Pickens (Dr. Richard Webber) describes his character in detail and explains why he admires him.
Actor T.R. Knight (Dr. George O'Malley) tells how he got to audition for the show.
Actress Chandra Wilson (Dr. Miranda Bailey) reveals what she admires about her character and how Dr. Bailey is an inspiration for others.
Actor Patrick Dempsey (Dr. Derek Shepherd) and series creator Shonda Rhimes describe their initial meeting and misunderstanding.
Actress Sandra Oh (Dr. Cristina Yang) talks about her audition and lends insight into her character.
Actress Kate Walsh (Dr. Addison Shepherd) discusses how she enjoys playing the role of Addison and being the boss of the interns.
Actress Katherine Heigl (Dr. Isobel 'Izzie' Stevens) talks about her audition for the part of Izzie Stevens.
Series creator Shonda Rhimes discusses her inspiration for the series and writing & casting the show.
Actor T.R. Knight (Dr. George O'Malley) tells a story about hitting a taco stand awning with a U-Haul.
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