Victoria gets a visit from the son she always forgets (Chris Colfer) and Joy and Mitch (Tim Daly) debate their compatibility.
Joy decides to finally tell Mitch (Tim Daly) how she feels but a handsome dating coach gets in the way (Coby Bell). Victoria is surprisingly taken with a very Clevelandy screenwriter (Dan Lauria).
Elka needs Ross Barkley's (Chevy Chase) endorsement for City Council so Melanie gets strong-armed into going on a date with him. Meanwhile, Joy hides her feelings for Mitch (Tim Daly) while he tries to get over Melanie.
The women fly to Los Angeles to watch Victoria announce the Oscar nominations. Elka gets campaign advice from a statistics expert, Victoria has nerves over the unknown, and Joy meets the man she's going to marry.
Lines get blurred when Joy and Bob (Dave Foley) go undercover as a couple and Elka gets a political rival (Bill Bellamy).
Victoria resolves to come clean about something to her longtime friend, Maddie Banks (Kirstie Alley), but gets cold feet in this KIRSTIE crossover episode. Melanie, Joy, and Elka cross things off their bucket lists.
The ladies take their depressed puppy, George Clooney, to Dr. Deb, a pet therapist who has her own radio show (Cheri Oteri). Dr. Deb blames the women for George's bad behavior and gives them assignments to better their lives and their dog's.
Melanie uses her illness to get tickets to country star Chase Jackson's (Chris Isaak) sold-out concert, while her friends also cash in on her "tumor perks." Vicotoria's new online suitor may not be the man he says he is.
When the women try to adopt a puppy, the Rescue Center's volunteer, Doug (Max Greenfield), determines if they are dog-worthy. Elka's relationships with Mamie (Georgia Engel) and Roy (John Mahoney) take an interesting turn.
Victoria wants to be nominated for an Oscar and gets her friends to convince Academy members to nominate her. Melanie's assigned a teen idol (Jason Priestly); Joy's given an indie darling (Sarah Hyland). Elka reunites with Roy.
On the eve of Victoria's big movie premiere, Emmy (Jennifer Love Hewitt) visits with some surprising news while Elka announces she's taken a younger lover (Chris Elliott).
Elka (Betty White) throws a fake funeral for Victoria so she can join her husband in hiding. Her nemesis, Susan Lucci attends. Simon (Craig Ferguson) and Joy face a dilemma in their relationship.
Joy's baby daddy, Simon (Craig Ferguson), meets his son and grandson for the very first time as they pretend to be a happy family to get Wilbur into a prestigious pre-school. Melanie and Elka try to find the perfect doctor.
Since Victoria's husband's disappearance, the women have been monitored closely by an FBI agent (Thomas Lennon). Melanie tells Alec (Jay Harrington) that she's pregnant and Joy discovers she's now irresistible to men.
After Victoria's husband, Emmet, escapes prison, Victoria and the other women go to a hideout that Elka knows. When they arrive, they discover the hideout is double-booked with other criminals.
Season 5 of Hot in Cleveland delivers more twists and turns as the ladies juggle romances old and new, adopt a puppy and travel to New York to cross items off their bucket lists.
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