A patient with AIDS stalks House to get him to take his case; House and Stacy stalk a mouse in her attic; and Cameron faces a health scare of her own.
When a famous professional cyclist is brought in after collapsing during a race, House doesn’t want to treat him because he thinks he’s lying about doing drugs. But when the patient is forthcoming about taking all sorts of performance enhancers and blood-doping drugs, House is definitely intrigued. Cameron is upset the patient is a hero to kids when he is clearly cheating at his sport. She struggles with the ethical dilemma of patient confidentiality and considers going to the media. Meanwhile, House tries to disrupt Stacy and Mark’s relationship by attending a group therapy session with Mark.
When recent college graduate Carnell drops at a graduation party from internal shocks, he is rushed to Princeton Plainsboro Hospital. With his father Ken at his bedside, it becomes apparent the two have not been truthful with each other in their lives and their major trust issues affect how the medical team gets the information it needs to help solve Carnell's case. Carnell soon develops other symptoms, and House's team suspects it might be from a Spring Break trip out of the country, but have to dig deeper to get all the information. Meanwhile, House has his own issues with his father and is trying unsuccessfully to get out of a dinner engagement with his parents when they arrive in town.
When Dr. Sebastian Charles (guest star Ron Livingston, "Little Black Book," "Sex and the City"), renowned physician and head of an international organization to fight the spread of tuberculosis among the poor in Africa, is rushed to Princeton Plainsboro Teaching Hospital after collapsing, he immediately determines all the symptoms are from TB. Dr. House has a different opinion and requests additional tests to help determine the cause of his illness. The case begins to get media attention and Dr. Charles sees his chance to further his cause by refusing to submit to any additional tests and take necessary medication in order to gain media exposure for the inadequacies of the medical system for the poor in Africa. As House confronts his patient on live television, his medical condition deteriorates and the team takes over to try to save his life. Meanwhile, Foreman fills in for House in the clinic with disastrous results and Cameron sees eye to eye with Dr. Charles and his cause.
When Cuddy's handyman Alfredo, a young Latino and the sole provider for his family, falls from her roof and develops strange darkened pinkies, Cuddy joins the team in trying to figure out what's wrong with him. Despite everything the team tries, the whole hand becomes infected. As Cuddy struggles with worry and guilt, House and his team are forced to amputate Alfredo's hand so they have more time to diagnose the illness before it kills the patient. However, when Alfredo's other hand starts showing the same symptoms, the doctors look outside the hospital for answers. A trip to the young man's neighborhood helps them understand Alfredo's desire for a better life for his family, and provides a clue as to what might be causing his deadly illness.
Andie, a 9-year-old terminal cancer patient, is brought in after suffering from a hallucinogenic episode. Wilson convinces House to take the case, but he and his team struggle to diagnose what caused the hallucination. Andie handles the reality of her terminal medical situation remarkably well, so well that House questions the sincerity of her bravery and considers the possibility it may be a medical symptom. Meanwhile, Andie's request to experience one of life's great "firsts" forces Dr. Chase to make a difficult personal decision. House has an idea of what's causing Andie's medical emergency, but puts the decision in her hands as to whether to take on an extremely risky experimental treatment, one that may end her life even sooner than her terminal illness.
When Death Row inmate Clarence (guest star LL Cool J) mysteriously and suddenly collapses after hallucinating, House jumps at the chance to take the case for its difficulty and because it's "cool." Dr. Cameron refuses to treat the patient in protest and feels they should treat a cancer patient because she's more deserving, raising the question: is one life more important than another? Meanwhile, House and Stacy (guest star Sela Ward) are adjusting to her working at the hospital. As House goes though his diagnostic process, including having a drink or three with his prisoner patient, Dr. Cameron must come to terms with the fact that she just might not be able to help every patient.
House is faced with a problem he may not be able to solve and Stacy returns.
House must decide whether to take the case of his ex-love's husband and he gives medical students a lecture they'll never forget.
House and his team tackle the case of a young man with a penchant for odd behavior, and House prepares for his date with Cameron.
House and his team race to diagnose a 12-year-old's illness - an illness with a shocking origin - and House asks Cameron to come back to her job.
House and his team battle to diagnose a pregnant patient's life-threatening illness, prompting her to make the most emotional decision of her life, and Vogler is determined to fire House.
House and his team battle to save a presidential hopeful, and House refuses to give in to Vogler's ultimatum when given the chance to save one of his team members.
Dr. House and his team try to uncover the reason a 10-year-old has a heart attack while House suspects one of his team is selling him out to Vogler.
Dr. House and his team race to diagnose a member of the mob and get him well enough to testify and enter the witness protection program while Cuddy works to convince Vogler of House's importance to the hospital.
The hospital's new Chairman of the Board has it out for Dr. House, questioning his importance to the hospital and threatening to eliminate House and his team.