Jackie is nervous about her date with Frank, so Zoey and Thor help her get ready and Eddie offers some friendly pointers. Prentiss misdiagnoses an injured dancer. Mike Cruz calls Jackie in a moment of need.
A heavily medicated Jane Doe is brought into the ER and Jackie tasks Zoey with finding out who she is. Jackie faces conflict with both her daughters - Fiona has been acting out while Grace sneaks around with her older boyfriend.
After their custody meeting, Jackie rear-ends Kevin and wakes up as a patient in her own ER. When Carrie checks on Jackie, she writes her a prescription for Oxy, unaware she's an addict.
Jackie and Kevin are at a stalemate in their divorce mediation. Coop is angry that he isn't named Chief of the ER. Jackie, overwhelmed by the day, vents to the only person who will understand - Charlie Cruz.
Season 5 premiere. Two new doctors join the staff: Dr. Carrie Roman (Betty Gilpin) and Dr. Ike Prentiss (Morris Chestnut). Akalitus (Anna Deavere Smith) gives Eddie (Paul Schulze) back his old job - the day before Jackie's (Edie Falco) birthday.
Season 4 finale. Cruz pushes Jackie to the breaking point then fires her; Jackie enrolls Grace in public school; O'Hara goes into labor.
Season 4. Jackie seizes control of an overflowing emergency room and runs it her way; Cruz suffers a pulmonary episode.
Season 4. Cruz takes revenge on Jackie's coworkers for their history of covering up her addiction; Eddie offers support for Jackie's case during his deposition to Kevin's lawyer; O'Hara finally leans on Coop.
Jackie covers for Cruz when he has a panic attack; Zoey surveys her coworkers for the best ways to conduct a breakup; Akalitus enlists the staff in an elaborate charade when her mentor is admitted with dementia.
Jackie has a disturbing dream about using; Coop insists on being involved with O'Hara's child; Zoey loses her engagement ring; O'Hara takes action on Jackie's behalf when Kevin sues for full custody of the kids.
Jackie invites Kevin to meet her at a cafe but is served divorce papers instead of lunch; Cruz institutes a draconian new dress code that is not a hit with his staff; Zoey looks for a new roommate and finds one in the lonely Jackie.
Jackie learns that Grace knows the truth about rehab and races to tell Kevin before he hears about it from their daughter; Cruz docks Jackie's pay for supplies she stole; Jackie asks Charlie to meet her at an AA meeting but he shows up drunk.
Jackie leaves rehab early against her therapist's advice and finds that returning to work rattles her nerves and challenges her sobriety; Zoey has second thoughts about Lenny; Eddie tells Jackie that he confessed their affair to Kevin.
Jackie detoxes in rehab, where she faces the truth about how her drug dependency began and forges a surprising alliance with 17-year-old fellow addict Charlie; Cruz's innovations continue to irritate everyone on the All Saints staff except for Coop.
In the Season 4 premiere, Jackie hits rock bottom and seeks professional help, while All Saints is taken over by a corporation whose new director Mike Cruz makes a shocking personnel change; Kevin learns the truth about Eddie and Jackie.
ER nurse Jackie Peyton finally confronts her addiction. But when an ambitious new hospital administrator (Bobby Cannavale) joins the staff and starts making waves, Jackie's newfound sobriety is tested to the limits.
Executive Producers Clyde Phillips and Tom Straw discuss Jackie choosing between Frank and Dr. Cruz.
Zoey helps Dr. Prentiss with a patient.
Akalitus forgets to hire an escort for a psych patient who ends up laying waste to the pharmacy.
Zoey hears Coop and Carrie having sex. Jackie worries about Frank.
Jackie recoups from her night of indiscretion. Cruz has his exit interview.
Jackie seeks advice from Eddie.
Dr. Cruz shows up at All Saints for his exit interview.