Three Rivers goes inside the emotionally complex lives of organ donors, the recipients. Dr. Andy Yablonski, the highly- skilled workaholic lead organ transplant surgeon, whose good- natured personality and sarcastic wit makes him popular with his patients. His co-workers include Dr. Miranda Foster, a surgical fellow with a rebellious streak; Dr. David Lee, a womanizing surgical resident who's broken as many hearts as he's replaced; and Ryan Abbott, the inexperienced new transplant coordinator.