On the season ten finale, the doctors bid farewell to Cristina Yang.
With Derek away, Meredith spends time with Amelia and finds out her true feelings about her time in Seattle. Bailey deals with the ramifications of her actions and Callie receives devastating news.
Cristina looks to Meredith for advice as she assesses her future.
Jackson is given the daunting task of delivering disappointing news.
Cristina enlists Meredith to help her prepare an acceptance speech.
Cristina won't let herself get excited when she is nominated for a Harper Avery award; Alex thinks about making a change; Callie and Derek work with a machine that recognizes emotions.
The doctors are exposed to flu-infected patients; Derek prepares to give a speech; a new doctor gives Alex a glimpse into an alternative medical practice.
Cristina thinks about her future; a patient decides whether to live or not.
Bailey asks Richard to join her on the case of a lifetime; Meredith decides to hire a research assistant; Callie shocks Derek; a young pregnant woman (Keke Palmer) needs Shane's help.
Arizona's bad day escalates when she advises a patient on a potential double amputation; Derek breaks a promise; Stephanie and Jo find an abandoned baby; the nonfraternization rule leads to a suspension.
Couples panic when the hospital announces a nonfraternization policy; Owen and Emma discuss the future; Meredith and Cristina have some girl time; Richard asks the residents for help with a rare cancer case.
The doctors are faced with the consequences of the events at April's wedding; Alex reacts to the news about his father; Callie and Arizona make a decision about their relationship.
Meredith and Cristina bicker about their careers; Bailey talks to Ben about him moving back to Seattle; Shane puts himself in a risky situation; Derek receives a life-changing phone call.
April's visiting sisters get on her nerves; when Matthew and Jackson witness an accident, they must work together; Callie and Arizona work on their relationship.
Ben worries that an innocent conversation with Derek could end up causing problems for Bailey; Cristina turns to Shane as tension with Meredith increases; April's upcoming wedding creates an uncomfortable situation for Stephanie and Jackson.
As Callie is faced with a malpractice suit, her supportive father (Hector Elizondo) visits and shares a secret; past details about Callie and Arizona's marriage are revealed.
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