A famous civil war photographer realizes he may be taking his last picture after Dr. Mike discovers that he is going blind.
Dr. Mike discovers Hank's dark secret -- an illegitimate son.
Dr. Mike faces the most difficult challenge of her career when she is forced to operate on Brian after he suffers a brain injury.
Influenced by the pulp romance novels she loves, Colleen develops her first crush -- on Sully -- and schemes a way for him to rescue her from danger.
Matthew and Michaela are at odds over his future when he sets out to prove to others -- and to himself -- that he's a grown man ready to take on life -- and decides to marry Ingrid.
As Dr. Mike's birthday approaches, the kids decide to do something about her unmarried status
When Cheyenne medicine man Cloud Dancing is wounded by General Custer, who intends to hang him, Sully and Dr. Mike join forces to help him escape.
"Progress" comes to Colorado Springs, and Sully pays the price.
A wandering cowboy abandons his baby boy and leaves him in Dr. Mike's care.
When Doc Eli, a medicine-show man, arrives in town professing to have created the perfect bottled elixir, Mike sets out to call his bluff, especially when her children's health becomes jeopardized.
When the town's water supply is tainted with mercury by a wealthy mining baron, many people become sick and Dr. Mike threatens the miner to clean it up or have his land taken away.
Michaela worries when Charlotte's husband, Ethan Cooper, comes back to the family he abandoned, convincing almost everyone of his newfound ways.
Loren, the unforgiving father-in-law, threatens to take back Sully's homestead.
When a starving orphaned immigrant takes desperate measures to feed his siblings, the only thing standing between him and a noose is Kid Cole, the new sheriff.
Mike's stoic, disapproving Bostonian mother, Elizabeth, who, after years of estrangement, visits her daughter in Colorado Springs but finds her unconventional life on the frontier difficult to accept.
Dr. Quinn immediately takes action to stop the spread of a deadly epidemic.
Dr. Michaela "Mike" Quinn, daughter of a doctor, leaves her stable life in Boston -- answering an ad for a town doctor in Colorado Springs.