Pauline isn't your typical teen. She picks scabs, dissects road kill, and fantasizes about performing surgery on strangers. Her fascinations disturb her parents and her classmates. Pauline reserves special disdain for "the church" and her "therapist," Reverend William, who, in Pauline's mind, is in no position to judge, or indulge in, her psychosexual fantasies. No one understands Pauline except for Grace, her younger sister, who suffers from cystic fibrosis. An outcast at school and at home, Pauline decides she is ready to lose her virginity, and this is when the weirdness really begins.