When J.D. (Zach Braff) and Turk (Donald Faison) are paid a visit by their college cohort, Spence (guest star Ryan Reynolds) -- who is now leading a life of luxury as an investment banker -- they are struck by the daily sacrifices they make as residents leading them to re-evaluate their career choices. Spence's visit also triggers the reveal of another dirty little secret - Dr. Cox (John C. McGinley) learns the truth about his relationship to Jordan's (guest star Christa Miller Lawrence) baby, but the truth may be more than he can handle. Meanwhile, Elliot's (Sarah Chalke) skills and patience are tested by the unrelenting Dr. Kelso (Ken Jenkins). Judy Reyes and Neil Flynn also star.