J.D.'S (Zach Braff) efforts to make a good impression on a first date reach desperate levels when he and Kylie (Chrystee Pharris-Larkins) get caught in a hospital quarantine. A series of unfortunate events bring J.D. and Kylie to Sacred Heart on their first date, where J.D. accidentally initiates a SARS quarantine and is forced to resort to desperate measures to make a good impression. While the hospital is in lockdown, the rest of the staff recounts various first date stories leading to the revelation that Dr. Cox (John C. McGinley) and Carla (Judy Reyes) dated in the past. Tara Reid guest stars as J.D.'s ex-girlfriend.