In the emotional series finale, directed by series creator and executive producer David Shore, treating a drug addict patient (guest star James LeGros, "Mildred Pierce") results in House examining his life, his future and his own personal demons.
The team takes on the case of Derrick (guest star Skylar Astin), a 19-year-old college student who had a mysterious nose bleed during cheerleading practice, and discovers that his health issues are likely both physiological and psychological. Possibly suffering from schizophrenia, Derrick claims to hear his deceased brother’s voice in his head. Meanwhile, Wilson gets advice from former colleague Thirteen (guest star Olivia Wilde) and Foreman tries a different approach with House.
In an episode directed by and guest-starring Peter Weller, the team takes on the case of Dr. Peter Treiber (guest star Jamie Elman), a pathologist at Princeton-Plainsboro Teaching Hospital who knows too much about the hospital staff to trust any of the physicians. The only person he does respect is House, who has mysteriously gone missing. With House in absentia, the team has to figure out how to treat Treiber while making him believe that House is calling all the shots.
When the team takes on the case of Emily, a six-year-old girl who has numerous preexisting health problems, they must work with her mother Elizabeth (guest star Jessica Collins), who happens to be a doctor herself, specializing in her daughter’s condition. The team must also deal with the battles raging between Emily’s mother and father who have conflicting views on how to handle her health issues. When searching the family’s home for clues to Emily’s illness, the team realizes that Elizabeth‘s determination to cure her daughter could be the very thing that is killing her. Meanwhile, House and Wilson take a little vacation.
House and the team take on the case of a young boy who has violent dreams of being choked, and then wakes up but still can’t take in air. Meanwhile, Park is having intimate dreams involving co-workers, which causes the team to question whether or not there’s significance to what each of them dreams, and Dominika discovers a secret that could ruin her relationship with House.
House and the team take on the case of a man who starts tearing blood. Meanwhile, House is interviewing for a new favorite hooker, since his current favorite, Emily, has decided to get married and leave the business. Desperate for Emily “companionship,” House teams up with his “wife” Dominika to sabotage Emily’s budding relationship.
House and the team take on the case of a 22-year-old minor league hockey player who collapsed while coughing up blood after a fight on the ice. Meanwhile, House drops a bomb on Wilson, and Chase offers to help Park change her living arrangement.
The team treats an Army veteran charged with treason after he leaked classified information. But the patient’s life is put at risk when he refuses treatment unless he and his brother are given information about their late father, a war veteran, which raises questions about loyalty to one’s family and country. Meanwhile, Adams suspects House may be sick, so she recruits Wilson and the other team members to plan an intervention and investigate his illness.
House and the team battle to save a successful, independent blind man (guest star Michael B. Jordan) who is struck down by a mysterious illness, just prior to him asking for his girlfriend’s hand in marriage. Meanwhile, House’s mother (guest star Diane Baker) unexpectedly arrives at Princeton Plainsboro to inform him of her new beau (guest star Billy Connolly).
A marriage counselor collapses during a speaking engagement, but when he is put under close evaluation, the team notice changes in his behavior that conflict with his motivational message on the roles of men and women. Meanwhile, House and his Ukrainian “wife” Dominika (guest star Karolina Wydra) make a deal to convince Immigration that they are a happily married couple. Also, House decides to name a team leader.
Chase takes on a patient, Moira (guest star Julie Mond), who is a cloistered nun on the verge of making her life-changing vows, and through the treatment process, he and Moira form a unique connection that tests their faith and reason. But when Moira's condition worsens and requires a risky surgery, Chase's judgment is compromised. Meanwhile, House and Taub try to remain one step ahead of each other's pranks.
When a violent incident involving a patient has serious consequences, House and the team are placed under review by Dr. Walter Cofield (guest star Jeffrey Wright), Foreman's former mentor. As House and each member of his team recount the details of the dramatic and life-threatening incident, Cofield must weigh the team's unconventional brand of collaboration against their ability to save lives.
The team treats an underage and homeless female patient (guest star Bridgit Mendler), but when her symptoms worsen and call for an invasive surgery requiring adult consent, House and Adams argue over whether they should contact social services. The patient confesses that she ran away from home after struggling to take care of her mother, a recovering drug addict. But when her mother appears at her bedside, a more complicated relationship is revealed and the patient's mother must put the past aside and make the best decision for her daughter. Meanwhile, Taub has a difficult time connecting with his infant daughters and House threatens to exploit Foreman's relationship with a married woman (guest star Yaya DaCosta).
An Alzheimer's patient visits Princeton Plainsboro as part of a hospital sanctioned drug trial, but when he inexplicably suffers from violent vomiting and an increasingly explosive temper, the team begins to unravel a deeper marriage conflict between the patient and his dutiful wife. Meanwhile, House and Foreman butt heads, and Wilson treats a patient who claims to be in a chaste marriage.
A prosecutor suffers from what he believes to be cardiac arrest during an interrogation at the witness stand. The team's preliminary diagnosis is hyper-anxiety, but when Adams and Park investigate the patient's home and find a hidden arsenal of firearms, they uncover a more alarming and deep-seated psychological disorder. Also, Wilson becomes obsessed with proving that House is hiding something in his home, Park slowly comes out of her social shell and Foreman's lack of romantic relationships piques the interest of Taub and Chase.
House M.D. clip - starring Hugh Laurie, Robert Sean Leonard, Lisa Edelstein, Omar Epps, Jesse Spencer, Jennifer Morrison.
House M.D.: The Softer Side clip - starring Hugh Laurie, Robert Sean Leonard, Lisa Edelstein, Omar Epps, Jesse Spencer, Jennifer Morrison. Directed by Deran Sarafian.
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Meet the cast of House.
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House sneak peek.
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House's private investigator proves to not be as smart as he thought...
A girl is admitted to the hospital with smallpox, and the CDC institutes a lockdown.
House Sneak Peek
House sneak peek
House M.D.: The Greater Good clip - starring Hugh Laurie, Robert Sean Leonard, Lisa Edelstein, Omar Epps, Jesse Spencer, Jennifer Morrison. Directed by Lesli Linka Glatter.
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