Danny (Patrick Breen) is a handsome museum curator who is cheating on his fiancee, Edwina, with a floozy blond waitress, Cheryl. Edwina stumbles upon Danny attempting to have sex with Cheryl in a basement gallery that's under construction. All three are unintentionally locked in for the night by the staff. Danny accidentally wakens a 3,000-year-old Incan mummy witch (Pamela Dean Kelly) after exposing it to a bloody handkerchief. The mummy was rejected by her lover in the past, and now seeks vengeance on all male lotharios.