As Pope Alexander (Jeremy Irons) fights for his life after being poisoned, the Cardinals jockey for position to take over the Papacy. Cesare (Francois Arnaud) and Micheletto (Sean Harris) trace the assassination plot back to its source, but Della Rovere (Colm Feore) is ready to make his move -- and his is not the only conspiracy. Catherina Sforza (Gina McKee) has dispatched her own personal assassin Rufio (Thure Lindhart) to dethrone the Borgia family. However, thanks to Lucrezia's quick thinking (Holliday Grainger), the family's grip on power may not be lost.
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