When her father tells heart-broken Lucrezia that Paolo's suicide cannot be given a Christian funeral and will go to Hell, she refuses to feed either herself or her baby. Worried for his grandson, Alexander relents, but he also suspects what she has already realized: Juan murdered him. Soon however, the family faces a greater threat. The French army is marching from Naples, King Charles is eager for vengeance for having been tricked by Alexander, and what's worse, his forces are backed by those of Giovanni Sforza, Lucrezia's humiliated ex-husband, and his powerful cousin Catherina. The French lay siege to Rome once more and this time it seems the city must fall to Charles' superior artillery. But Cesare concocts an elegant plan and works with Vittoria to outwit the French once again. Meanwhile, Della Rovere has arrived in Rome unnoticed, seeking conspirators for his new plot to assassinate the Pope.