Life in suburban Serenity, Ohio is never quite as serene as it appears. The dysfunctional Burnett family Bunnie (Hope Davis), Jack (Dermot Mulroney) and their twin 17 year olds Eric (Max Thieriot) and Kelly (Britt Robertson) seems like a lost cause. When a freak accident leaves Bunnie with a case of amnesia, the Burnetts get an unexpected second chance at happiness. Meanwhile, next door neighbor Simon (Chi McBride) is relieved that his tryst gone wrong with Bunnie remains undetected, at least for the moment. Before long, a slew of past relationships, kids with guns, a suicidal teacher, a very zealous religious club, misinterpreted advances, corporate down-sizing, and one fateful squirrel combine to create enough mayhem to test the resolve, sanity and future of any family!