On a boring, rainy weekend, Charlie convinces Alan to ride with Jake and him to Las Vegas. Apprehensive about his upcoming colonoscopy, Alan agrees that the diversion will be good for him. After Alan packs numerous suitcases, and the guys are ready to leave, Jake becomes physically ill. Judith visits the house and then forbids Alan to take Jake anywhere without her permission. Alan and Charlie want to defy Judith, but when Jake becomes ill again, the two brothers realize they must be responsible adults and stay home.
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