Oh Mi Sun (Jang Shin Yeong), a stewardess who manages the drinks and food on the "red-eye" train from Yeosu to Seoul, is working during the train's final run before it will be retired.
Lisa Reisert (Rachel McAdams) is a young woman with more than her share of anxieties about flying. However, when circumstances demand she go to Miami, she gathers her nerves and books a seat on a late-night flight. Sitting next to her is a handsome and charming man named Jackson (Cillian Murphy), whom she already met in the airport, but once their jet is safely in the air, Lisa discovers he's not the pleasant traveling companion she imagined. Jackson is part of a terrorist cell plotting to kill the head of Homeland Security, and he's decided to draft Lisa into helping him. While Lisa has no interest in abetting Jackson's plan, he soon reveals he's holding a trump card — his compatriots are holding Lisa's father hostage, and will kill him if she doesn't cooperate.
A jilted photographer sets off to get back at her philandering model boyfriend - but a series of disastrous dates makes finding new love a challenge!
A woman in search of her one true love encounters one hilarious circumstance after another.
Moments after takeoff, Lisa's seatmate, Jackson (Cillian Murphy), menacingly reveals the real reason he's on board: He is an operative in a plot to kill a rich and powerful businessman .... And Lisa is the key to its success. If she refuses to cooperate, her father will be killed by an assassin awaiting a call from Jackson.
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