After undergoing treatment in rehab, Catherine returns to face the fallout at home and at The Cube. While trying to get her life back on track, Esme's biological father arrives and is in desperate need of a transplant.
Catherine refuses to be admitted into a hospital.
After experiencing hallucinations, Catherine ignores Dr. Hartramph’s advice to check into a hospital and have her medication rebalanced. Catherine needs to prepare for a TED Talk she is giving in Boston, but she may never get there as her symptoms intensify. With the botched surgery from 111 fresh on his mind, Bickman has his PTSD treated by Lina so he can get back into the operating room. Local mother, Mira, is brought into the Cube where they realize her sudden bravery is actually the absence of fear, a side effect of a rare syndrome known as Kluver-Bucy.
After her public breakdown, Catherine has issues to face at home and at work. At home, she finds out that Esme’s biological father has Leukemia and is in need of a marrow transplant from a blood relative causing Joshua and Reagan to tell Esme who her real parents are. At the Cube, Mahmoud reveals Catherine’s bipolar diagnosis to Owen who must decide if Catherine can continue working there; but Bickman steps in to argue that Mahmoud should be fired for breaking doctor/patient confidentiality. Will Catherine lose Esme and her job?
After undergoing treatment in rehab, Catherine returns to face the fallout at home and at The Cube. While trying to get her life back on track, Esme's biological father arrives and is in desperate need of a transplant. Catherine is faced with the difficult decision of having to reveal the truth to Esme about who her real parents are. Owen is agreeable to having Catherine back at work, though it isn't without strict parameters, making it a challenge for Catherine to earn her credibility back.
Dr. Bickman's doorman collapses from an aneurysm.
Bickman’s doorman Joey has bleeding in his brain from a brain aneurysm, and a second bleed is imminent, and likely to be fatal. During surgery, Bickman causes a complication that he has never experienced- massive bleeding. He has four minutes to repair the damage or it will result in permanent brain damage. Catherine confesses to Josh and Reagan that she told Will that Esme is her daughter. Hartramph tells Catherine that she did this to distract Will in order to hide her affair with Bickman. Catherine tells Will it’s over between them.
Dr. Bickman rushes his doorman to The Cube after he sees him collapse from a buried aneurysm. With a second bleed imminent, he makes a choice to perform an alternative procedure to repair it. After revealing a difficult diagnosis to a young mother, Catherine finds herself sinking into a deep sadness. In her desperation, she misleads a nurse into supplying her with oxycodone. Catherine turns to her brother for help, though he begins to wonder if he's become an enabler. Catherine reveals to Will that their relationship is over.
Dr. Morely admits a patient who is convinced he is dead.
Lucia, 16, is brought into the Cube by her parents after many other doctors and hospitals have failed to diagnose the cause of her arm twitches, slurred speech and inability to finish her sentences.. After talking to Erica, Catherine learns that she went to camp upstate and she fears that Erica may have rabies. The test comes back positive and the disease has clearly spread to her brain. It is too late but her parents demand that Catherine find a cure. Also in the Cube, a man who was in a motorcycle accident weeks ago insists that he died in the accident and that he is now walking dead, in hell. Esme busses tables at Will’s restaurants and accidentally reveals to Will that the Hotel Mirabella is where Bickman lives, not where Catherine went for a conference.
Dr. Black begins work on a music study where her patients range from a popular music competition winner that has lost her ability to recognize music pitch, to a man that has developed Acquired Savant Syndrome after being struck by lightning.
Catherine is doing a study on the effects of music on the brain. A saxophonist plays beautiful, haunting music on a New York Street corner, but is taken to the Cube when he begins to lose his ability to play. Catherine discovers that he has a benign essential tremor, and the tremor worsens with movements of intention. Also in the hospital is a man who has been struck by lightning and is now being treated for memory deficits and everyday he becomes progressively more interested in playing and listening to the violin. It is an actual alteration in his brain caused by the lightning strike. Catherine finds she is concerned about Bickman after he was shot and may have real feelings about him.
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