Bree (Felicity Huffman) is a perfectly adjusted conservative transsexual woman. Born Stanley, a genetic male, she's about to take the final step to becoming the woman Stanley always wanted to be - until she finds out that she is the parent of a long-lost 17 year-old son (Kevin Zegers). Afraid to tell the rebellious teenager the truth, Bree embarks on a journey with him that will challenge and change both their lives and bring them closer to the truth of their connection. Transamerica is a funny, touching, completely modern look at the modern American family, starring Emmy award winner Felicity Huffman and Kevin Zegers. Transamerica has won numerous festival prizes, including awards for best film at the Berlin Film Festival, San Francisco's Frameline festival and the Woodstock Film Festival, and the award for Best Screenplay at France's 2005 Deauville Festival of American Film.

Three generations of top actresses - two-time Academy Award winner Jane Fonda, Lindsay Lohan and Felicity Huffman - unite in a film from director Garry Marshall about the power of redemption, freedom in forgiveness and the unbreakable bonds of motherhood. When Lilly (Huffman) can no longer handle her rebellious teenage daughter, Rachel (Lohan), she takes her to the one place she swore she'd never return?her mother's house. For one very surprising summer, these three very different women are living under one roof and under one rule: Georgia's (Fonda).

Three generations of top actresses - two-time Academy Award winner Jane Fonda, Lindsay Lohan and Felicity Huffman - unite in a film from director Garry Marshall about the power of redemption, freedom in forgiveness and the unbreakable bonds of motherhood. When Lilly (Huffman) can no longer handle her rebellious teenage daughter, Rachel (Lohan), she takes her to the one place she swore she'd never return?her mother's house. For one very surprising summer, these three very different women are living under one roof and under one rule: Georgia's (Fonda).

After ending it all Mary Alice Young (Brenda Strong) takes us into the lives of her family, friends, and neighbors on Wisteria Lane. Her small circle of girlfriends includes Susan Mayer (Teri Hatcher), the divorcee and single mom; Lynette Scavo (Felicity Huffman), the ex-career woman who traded the boardroom for boredom with four unmanageable kids; Bree Van De Kamp (Marcia Cross), the Martha Stewart on steroids; and Gabrielle Solis, the ex-model with everything she's ever wanted so what is she doing with the 17-year-old gardener? From her unique vantage point, Mary Alice sees more than she ever did alive, and she's planning to share all the delicious secrets that hide behind every neighbor's closed door in this seemingly perfect American suburb.

The Spammies: The best spam emails are honored in this awards show. Presenters include Rita Rudner (Rachel Dratch), Megan Mullally (Kristin Wiig), and Peter Gallagher (Bill Hader) (Eva Longoria). Vincent Price Thanksgiving: A 1958 Thanksgiving Special starring Vincent Price (Bill Hader) and featuring Lucille Ball (Eva Longoria), Desi Arnaz (Fred Armisen), Clark Gable (Darrell Hammond), Judy Garland (Kristen Wiig), and Alfred Hitchcock (Horatio Sanz). Weekend Update: Steve Jobs: Fred Armisen is Steve Jobs, introducing new iPods. Desperate Housewives on Vanity Fair: The real story about Desperate Housewives Vanity Fair cover shoot, featuring Teri Hatcher (Eva Longoria), Marcia Cross (Amy Poehler), Eva Longoria (Rachel Dratch), Felicity Huffman (Kristin Wiig) and Nicolette Sheridan (Seth Meyers). German Family Band: A German family sing songs, including some that point to a fatal hunting accident (Eva Longoria, Seth Meyers, Fred Armisen, Bill Hader).

Felicity Huffman discusses the wonders of working with writing legends David Mamet, Stephen King and Aaron Sorkin.

Doug Savant presents to Felicity Huffman at the Breakthrough Awards, which is an annual event of Hollywood Life Magazine.

Think you know Felicity Huffman? Test your celebrity knowledge with Fact or Fiction.

Matt Mitovich interviews Felicity Huffman on the Desperate Housewives future.

Desperate to learn more about two of your favorite stars at the Breakthrough Awards? Find out how much these two really know about each other.