The Pussycats search for the Evil Eye, a mysterious figure with hypnotic powers, who has kidnapped Valerie and an Arabian princess.

After checking in at the Bombay Tilton Hotel, Alan, Josie and Alexandra are kidnapped by Kaseem, a political usurper who leads a band of hooded scalawags called the Secret Six, and taken to his sanctuary.

On their way to Pago Pago for a musical stint, Josie and her companions find themselves in troubled waters when the ship on which they are sailing is torpedoed by Captain Nemo, a swarthy scoundrel intent on avenging his great grandfather's name by sinking every ship in the world.

Over the Amazon, the companions become part of a cargo drop on Dr. Greenthumb's supply zone. Greenthumb, a diabolical scientist who schemes to destroy all living flora with his lethal creature plants, brings the group to his plantation where he sends them for a walk along his deadly garden path.

A skiing vacation in the Alps accidentally leads the gang to the mountain fortress of Midas, a gold hoarder who has invented a gold-destroying blue microbe mist with which he is seeking to dissolve the world's supply of gold.

Based on the animated hit TV show of the 1970s, Josie and the Pussycats is a live-action tale of a group of young girl rockers who desire to make it big. Josie (Rachael Leigh Cook), Val (Rosario Dawson), and Melody (Tara Reid) make up an aspiring garage band that is discovered by shady megalomaniac executive Wyatt Frame (Alan Cumming), the sidekick to MegaRecords boss Fiona (Parker Posey), who runs an industry powerhouse that has been grooming the very successful boy band Du Jour. Unbeknownst to the band, MegaRecords is a company whose real intent is to brainwash young people, with subliminal messages inserted in CDs to assure a healthy sales record. Josie and her crew soon latch on to the real deal behind their new label and are forced to choose between their burgeoning rock-star success and doing what's right for future music lovers. The film also stars Gabriel Mann as Josie's love interest/folk singer Alan M. Its soundtrack features work by Counting Crows' Adam Duritz, the Go-Go's Jane Wiedlin, and Babyfac